Protease-independent action of tissue plasminogen activator in brain plasticity and neurological recovery after ischemic stroke

Emerging evidence suggests that tissue plasminogen activator (tPA), currently the only FDA-approved medication for ischemic stroke, exerts important biological actions on the CNS besides its well-known thrombolytic effect. In this study, we investigated the role of tPA on primary neurons in culture...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Pu, Hongjian, Shi, Yejie, Zhang, Lili, Lu, Zhengyu, Ye, Qing, Leak, Rehana K., Xu, Fei, Ma, Shubei, Mu, Hongfeng, Wei, Zhishuo, Xu, Na, Xia, Yuguo, Hu, Xiaoming, Hitchens, T. Kevin, Bennett, Michael V. L., Chen, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500126/
https://ncbi.nlm.nih.gov/pubmed/30996120
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1821979116
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