Tissue plasminogen activator promotes white matter integrity and functional recovery in a murine model of traumatic brain injury

Recombinant tissue plasminogen activator (tPA) is a Food and Drug Administration-approved thrombolytic treatment for ischemic stroke. tPA is also naturally expressed in glial and neuronal cells of the brain, where it promotes axon outgrowth and synaptic plasticity. However, there are conflicting rep...

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Detalhes bibliográficos
Publicado no:Proc Natl Acad Sci U S A
Main Authors: Xia, Yuguo, Pu, Hongjian, Leak, Rehana K., Shi, Yejie, Mu, Hongfeng, Hu, Xiaoming, Lu, Zhengyu, Foley, Lesley M., Hitchens, T. Kevin, Dixon, C. Edward, Bennett, Michael V. L., Chen, Jun
Formato: Artigo
Idioma:Inglês
Publicado em: National Academy of Sciences 2018
Assuntos:
PNAS Plus
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6166834/
https://ncbi.nlm.nih.gov/pubmed/30201709
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1810693115
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