Cytosolic Fe-superoxide dismutase safeguards Trypanosoma cruzi from macrophage-derived superoxide radical

Trypanosoma cruzi, the causative agent of Chagas disease (CD), contains exclusively Fe-dependent superoxide dismutases (Fe-SODs). During T. cruzi invasion to macrophages, superoxide radical (O(2)(•−)) is produced at the phagosomal compartment toward the internalized parasite via NOX-2 (gp91-phox) ac...

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Detalles Bibliográficos
Publicado en:Proc Natl Acad Sci U S A
Main Authors: Martínez, Alejandra, Prolo, Carolina, Estrada, Damián, Rios, Natalia, Alvarez, María Noel, Piñeyro, María Dolores, Robello, Carlos, Radi, Rafael, Piacenza, Lucía
Formato: Artigo
Idioma:Inglês
Publicado: National Academy of Sciences 2019
Assuntos:
PNAS Plus
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6500117/
https://ncbi.nlm.nih.gov/pubmed/30979807
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.1821487116
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