LncRNA SNHG1 contributes to sorafenib resistance by activating the Akt pathway and is positively regulated by miR-21 in hepatocellular carcinoma cells

BACKGROUND: Acquired resistance to sorafenib greatly limits its therapeutic efficiency in the treatment of hepatocellular carcinoma (HCC). Increasing evidence indicates that long noncoding RNAs (lncRNAs) play important roles in the resistance to anti-cancer drugs. The present study aims to explore t...

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Bibliografiske detaljer
Udgivet i:J Exp Clin Cancer Res
Main Authors: Li, Weidong, Dong, Xuesong, He, Changjun, Tan, Gang, Li, Ziyi, Zhai, Bo, Feng, Jing, Jiang, Xian, Liu, Chang, Jiang, Hongchi, Sun, Xueying
Format: Artigo
Sprog:Inglês
Udgivet: BioMed Central 2019
Fag:
Research
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499991/
https://ncbi.nlm.nih.gov/pubmed/31053148
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1177-0
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