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Structural design principles that underlie the multi-specific interactions of Gα(q) with dissimilar partners

Gα(q) is a ubiquitous molecular switch that activates the effectors phospholipase-C-β3 (PLC-β3) and Rho guanine-nucleotide exchange factors. Gα(q) is inactivated by regulators of G protein signaling proteins, as well as by PLC-β3. Gα(q) further interacts with G protein-coupled receptor kinase 2 (GRK...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Navot, Shir, Kosloff, Mickey
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499889/
https://ncbi.nlm.nih.gov/pubmed/31053791
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43395-0
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