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Structural design principles that underlie the multi-specific interactions of Gα(q) with dissimilar partners
Gα(q) is a ubiquitous molecular switch that activates the effectors phospholipase-C-β3 (PLC-β3) and Rho guanine-nucleotide exchange factors. Gα(q) is inactivated by regulators of G protein signaling proteins, as well as by PLC-β3. Gα(q) further interacts with G protein-coupled receptor kinase 2 (GRK...
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| Publicado no: | Sci Rep |
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| Main Authors: | , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Nature Publishing Group UK
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6499889/ https://ncbi.nlm.nih.gov/pubmed/31053791 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43395-0 |
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