Akt and STAT5 mediate naïve human CD4+ T-cell early metabolic response to TCR stimulation

Metabolic pathways that regulate T-cell function show promise as therapeutic targets in diverse diseases. Here, we show that at rest cultured human effector memory and central memory CD4+ T-cells have elevated levels of glycolysis and oxidative phosphorylation (OXPHOS), in comparison to naïve T-cell...

Descrizione completa

Salvato in:
Dettagli Bibliografici
Pubblicato in:Nat Commun
Autori principali: Jones, Nicholas, Vincent, Emma E., Cronin, James G., Panetti, Silvia, Chambers, Megan, Holm, Sean R., Owens, Sian E., Francis, Nigel J., Finlay, David K., Thornton, Catherine A.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
Soggetti:
Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499791/
https://ncbi.nlm.nih.gov/pubmed/31053703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-10023-4
Tags: Aggiungi Tag
Nessun Tag, puoi essere il primo ad aggiungerne! !

Documenti analoghi