Cell cycle plasticity driven by MTOR signaling: Integral resistance to CDK4/6 inhibition in patient-derived models of pancreatic cancer

Pancreatic ductal adenocarcinoma (PDAC), like many KRAS-driven tumors, preferentially loses CDKN2A that encodes an endogenous CDK4/6 inhibitor to bypass the RB-mediated cell cycle suppression. Analysis of a panel of patient-derived cell lines and matched xenografts indicated that many pancreatic can...

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Detalhes bibliográficos
Publicado no:Oncogene
Main Authors: Knudsen, Erik S., Kumarasamy, Vishnu, Ruiz, Amanda, Sivinski, Jared, Chung, Sejin, Grant, Adam, Vail, Paris, Chauhan, Shailender S., Jie, Tun, Riall, Taylor S., Witkiewicz, Agnieszka K.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499706/
https://ncbi.nlm.nih.gov/pubmed/30696953
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0650-0
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