APOBEC-induced mutations and their cancer effect size in head and neck squamous cell carcinoma

Recent studies have revealed the mutational signatures underlying the somatic evolution of cancer, and the prevalences of associated somatic genetic variants. Here we estimate the intensity of positive selection that drives mutations to high frequency in tumors, yielding higher prevalences than expe...

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Vydáno v:Oncogene
Hlavní autoři: Cannataro, Vincent L., Gaffney, Stephen G., Sasaki, Tomoaki, Issaeva, Natalia, Grewal, Nicholas K. S., Grandis, Jennifer R., Yarbrough, Wendell G., Burtness, Barbara, Anderson, Karen S., Townsend, Jeffrey P.
Médium: Artigo
Jazyk:Inglês
Vydáno: Nature Publishing Group UK 2019
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Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499643/
https://ncbi.nlm.nih.gov/pubmed/30647454
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41388-018-0657-6
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