MDM2 integrates cellular respiration and apoptotic signaling through NDUFS1 and the mitochondrial network.

Signaling diversity and subsequent complexity in higher eukaryotes is partially explained by one gene encoding a polypeptide with multiple biochemical functions in different cellular contexts. For example, mouse double minute 2 (MDM2) is functionally characterized as both an oncogene and tumor suppr...

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Veröffentlicht in:Mol Cell
Hauptverfasser: Elkholi, Rana, Abraham-Enachescu, Ioana, Trotta, Andrew P., Rubio-Patiño, Camila, Mohammed, Jarvier N., Luna-Vargas, Mark P. A., Gelles, Jesse D., Kaminetsky, Joshua R., Serasinghe, Madhavika N., Zou, Cindy, Ali, Sumaira, McStay, Gavin P., Pfleger, Cathie M., Chipuk, Jerry Edward
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499641/
https://ncbi.nlm.nih.gov/pubmed/30879903
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.molcel.2019.02.012
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