CRISPR Gene Drive Efficiency and Resistance Rate Is Highly Heritable with No Common Genetic Loci of Large Effect

Gene drives could allow for control of vector-borne diseases by directly suppressing vector populations or spreading genetic payloads designed to reduce pathogen transmission. Clustered regularly interspaced short palindromic repeat (CRISPR) homing gene drives work by cleaving wild-type alleles, whi...

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Bibliographische Detailangaben
Veröffentlicht in:Genetics
Hauptverfasser: Champer, Jackson, Wen, Zhaoxin, Luthra, Anisha, Reeves, Riona, Chung, Joan, Liu, Chen, Lee, Yoo Lim, Liu, Jingxian, Yang, Emily, Messer, Philipp W., Clark, Andrew G.
Format: Artigo
Sprache:Inglês
Veröffentlicht: Genetics Society of America 2019
Schlagworte:
Investigations
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6499522/
https://ncbi.nlm.nih.gov/pubmed/30918006
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.119.302037
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