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A targeted dominant negative mutation of the thyroid hormone α1 receptor causes increased mortality, infertility, and dwarfism in mice

Mutations in the thyroid hormone receptor β (TRβ) gene result in resistance to thyroid hormone. However, it is unknown whether mutations in the TRα gene could lead to a similar disease. To address this question, we prepared mutant mice by targeting mutant thyroid hormone receptor kindred PV (PV) mut...

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Uloženo v:
Vydáno v:Proc Natl Acad Sci U S A
Hlavní autoři: Kaneshige, Masahiro, Suzuki, Hideyo, Kaneshige, Kumiko, Cheng, Jun, Wimbrow, Heather, Barlow, Carrolee, Willingham, Mark C., Cheng, Sheue-yann
Médium: Artigo
Jazyk:Inglês
Vydáno: National Academy of Sciences 2001
Témata:
Biological Sciences
On-line přístup:https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC64989/
https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11734632/
https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.261565798
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