A targeted dominant negative mutation of the thyroid hormone α1 receptor causes increased mortality, infertility, and dwarfism in mice

Mutations in the thyroid hormone receptor β (TRβ) gene result in resistance to thyroid hormone. However, it is unknown whether mutations in the TRα gene could lead to a similar disease. To address this question, we prepared mutant mice by targeting mutant thyroid hormone receptor kindred PV (PV) mut...

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Pubblicato in:	Proc Natl Acad Sci U S A
Autori principali:	Kaneshige, Masahiro, Suzuki, Hideyo, Kaneshige, Kumiko, Cheng, Jun, Wimbrow, Heather, Barlow, Carrolee, Willingham, Mark C., Cheng, Sheue-yann
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	National Academy of Sciences 2001
Soggetti:	Biological Sciences
Accesso online:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC64989/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11734632/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.261565798
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