Parkinson’s disease-associated LRRK2-G2019S mutant acts through regulation of SERCA activity to control ER stress in astrocytes

Accumulating evidence indicates that endoplasmic reticulum (ER) stress is a common feature of Parkinson’s disease (PD) and further suggests that several PD-related genes are responsible for ER dysfunction. However, the underlying mechanisms are largely unknown. Here, we defined the mechanism by whic...

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Salvato in:
Dettagli Bibliografici
Pubblicato in:Acta Neuropathol Commun
Autori principali: Lee, Jee Hoon, Han, Ji-hye, Kim, Hyunmi, Park, Sang Myun, Joe, Eun-hye, Jou, Ilo
Natura: Artigo
Lingua:Inglês
Pubblicazione: BioMed Central 2019
Soggetti:
Research
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6498585/
https://ncbi.nlm.nih.gov/pubmed/31046837
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s40478-019-0716-4
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