Recombination and mutation during long-term gastric colonization by Helicobacter pylori: Estimates of clock rates, recombination size, and minimal age

The bacterium Helicobacter pylori colonizes the gastric mucosa of half of the human population, resulting in chronic gastritis, ulcers, and cancer. We sequenced ten gene fragments from pairs of strains isolated sequentially at a mean interval of 1.8 years from 26 individuals. Several isolates had ac...

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Veröffentlicht in:	Proc Natl Acad Sci U S A
Hauptverfasser:	Falush, Daniel, Kraft, Christian, Taylor, Nancy S., Correa, Pelayo, Fox, James G., Achtman, Mark, Suerbaum, Sebastian
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	National Academy of Sciences 2001
Schlagworte:	Biological Sciences
Online-Zugang:	https://ncbi.nlm.nih.govhttps://pmc.ncbi.nlm.nih.gov/articles/PMC64982/ https://ncbi.nlm.nih.govhttps://pubmed.ncbi.nlm.nih.gov/11742075/ https://ncbi.nlm.nih.govhttps://doi.org/10.1073/pnas.251396098
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