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Recombination and mutation during long-term gastric colonization by Helicobacter pylori: Estimates of clock rates, recombination size, and minimal age

The bacterium Helicobacter pylori colonizes the gastric mucosa of half of the human population, resulting in chronic gastritis, ulcers, and cancer. We sequenced ten gene fragments from pairs of strains isolated sequentially at a mean interval of 1.8 years from 26 individuals. Several isolates had ac...

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Main Authors: Falush, Daniel, Kraft, Christian, Taylor, Nancy S., Correa, Pelayo, Fox, James G., Achtman, Mark, Suerbaum, Sebastian
Format: Artigo
Jezik:Inglês
Izdano: The National Academy of Sciences 2001
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Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC64982/
https://ncbi.nlm.nih.gov/pubmed/11742075
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1073/pnas.251396098
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