CD4- and Time-Dependent Susceptibility of HIV-1-Infected Cells to Antibody-Dependent Cellular Cytotoxicity

HIV-1-specific antibody-dependent cellular cytotoxicity (ADCC) antibodies within HIV-1-positive (HIV-1(+)) individuals predominantly target CD4-induced (CD4i) epitopes on HIV-1 envelope glycoprotein (Env). These CD4i epitopes are usually concealed on the surface of infected cells due to CD4 downregu...

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Detalhes bibliográficos
Publicado no:J Virol
Main Authors: Lee, Wen Shi, Prévost, Jérémie, Richard, Jonathan, van der Sluis, Reneé M., Lewin, Sharon R., Pazgier, Marzena, Finzi, Andrés, Parsons, Matthew S., Kent, Stephen J.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Pathogenesis and Immunity
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6498039/
https://ncbi.nlm.nih.gov/pubmed/30842324
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/JVI.01901-18
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