Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers

The cellular prion protein (PrP(C)) is a key neuronal receptor for β-amyloid oligomers (AβO), mediating their neurotoxicity, which contributes to the neurodegeneration in Alzheimer's disease (AD). Similarly to the amyloid precursor protein (APP), PrP(C) is proteolytically cleaved from the cell...

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Vydáno v:J Biol Chem
Hlavní autoři: Jarosz-Griffiths, Heledd H., Corbett, Nicola J., Rowland, Helen A., Fisher, Kate, Jones, Alys C., Baron, Jennifer, Howell, Gareth J., Cowley, Sally A., Chintawar, Satyan, Cader, M. Zameel, Kellett, Katherine A. B., Hooper, Nigel M.
Médium: Artigo
Jazyk:Inglês
Vydáno: American Society for Biochemistry and Molecular Biology 2019
Témata:
Neurobiology
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497954/
https://ncbi.nlm.nih.gov/pubmed/30872401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005364
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