Proteolytic shedding of the prion protein via activation of metallopeptidase ADAM10 reduces cellular binding and toxicity of amyloid-β oligomers

The cellular prion protein (PrP(C)) is a key neuronal receptor for β-amyloid oligomers (AβO), mediating their neurotoxicity, which contributes to the neurodegeneration in Alzheimer's disease (AD). Similarly to the amyloid precursor protein (APP), PrP(C) is proteolytically cleaved from the cell...

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Veröffentlicht in:J Biol Chem
Hauptverfasser: Jarosz-Griffiths, Heledd H., Corbett, Nicola J., Rowland, Helen A., Fisher, Kate, Jones, Alys C., Baron, Jennifer, Howell, Gareth J., Cowley, Sally A., Chintawar, Satyan, Cader, M. Zameel, Kellett, Katherine A. B., Hooper, Nigel M.
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Biochemistry and Molecular Biology 2019
Schlagworte:
Neurobiology
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497954/
https://ncbi.nlm.nih.gov/pubmed/30872401
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.005364
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