Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane

Pannexin 1 (PANX1)-mediated ATP release in vascular smooth muscle coordinates α1-adrenergic receptor (α1-AR) vasoconstriction and blood pressure homeostasis. We recently identified amino acids 198–200 (YLK) on the PANX1 intracellular loop that are critical for α1-AR–mediated vasoconstriction and PAN...

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Publicado en:J Biol Chem
Autores principales: DeLalio, Leon J., Billaud, Marie, Ruddiman, Claire A., Johnstone, Scott R., Butcher, Joshua T., Wolpe, Abigail G., Jin, Xueyao, Keller, T. C. Stevenson, Keller, Alexander S., Rivière, Thibaud, Good, Miranda E., Best, Angela K., Lohman, Alexander W., Swayne, Leigh Anne, Penuela, Silvia, Thompson, Roger J., Lampe, Paul D., Yeager, Mark, Isakson, Brant E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Biochemistry and Molecular Biology 2019
Materias:
Cell Biology
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497939/
https://ncbi.nlm.nih.gov/pubmed/30814251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006982
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