Constitutive SRC-mediated phosphorylation of pannexin 1 at tyrosine 198 occurs at the plasma membrane

Pannexin 1 (PANX1)-mediated ATP release in vascular smooth muscle coordinates α1-adrenergic receptor (α1-AR) vasoconstriction and blood pressure homeostasis. We recently identified amino acids 198–200 (YLK) on the PANX1 intracellular loop that are critical for α1-AR–mediated vasoconstriction and PAN...

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Detalhes bibliográficos
Publicado no:J Biol Chem
Main Authors: DeLalio, Leon J., Billaud, Marie, Ruddiman, Claire A., Johnstone, Scott R., Butcher, Joshua T., Wolpe, Abigail G., Jin, Xueyao, Keller, T. C. Stevenson, Keller, Alexander S., Rivière, Thibaud, Good, Miranda E., Best, Angela K., Lohman, Alexander W., Swayne, Leigh Anne, Penuela, Silvia, Thompson, Roger J., Lampe, Paul D., Yeager, Mark, Isakson, Brant E.
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Cell Biology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497939/
https://ncbi.nlm.nih.gov/pubmed/30814251
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1074/jbc.RA118.006982
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