GADD45α-targeted suicide gene therapy driven by synthetic CArG promoter E9NS sensitizes NSCLC cells to cisplatin, resveratrol, and radiation regardless of p53 status

Background: GADD45α is a tumor suppressor protein often upregulated by environmental stresses and DNA-damage agents to cause growth arrest, apoptosis, tumor growth inhibition, and anti-angiogenesis. A novel suicide gene therapy vector pE9NS.G45α was engineered by cloning GADD45α opening reading fram...

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Detaylı Bibliyografya
Yayımlandı:Onco Targets Ther
Asıl Yazarlar: Shi, Qiwen, Sutariya, Vijaykumar, Varghese Gupta, Sheeba, Bhatia, Deepak
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Dove 2019
Konular:
Original Research
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497884/
https://ncbi.nlm.nih.gov/pubmed/31114253
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/OTT.S192061
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