Intrathecal TRPM8 blocking attenuates cold hyperalgesia via PKC and NF-κB signaling in the dorsal root ganglion of rats with neuropathic pain

Background: TRPM8 channel plays central roles in the sensitization of nociceptive transduction and is thought as one of the potential targets for the treatment of neuropathic pain. However, the specific molecular mechanisms are still less clear. Methods: Sciatic chronic constriction injury (CCI) rat...

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Publicado en:J Pain Res
Main Authors: Cao, Song, Li, Qingmei, Hou, Jingfeng, Li, Zhourui, Cao, Xinya, Liu, Xiaohong, Qin, Bangyong
Formato: Artigo
Idioma:Inglês
Publicado: Dove 2019
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Original Research
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497852/
https://ncbi.nlm.nih.gov/pubmed/31114308
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.2147/JPR.S197168
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