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Sustained morphine administration induces TRPM8 dependent cold hyperalgesia
It is not uncommon for patients chronically treated with opioids to exhibit opioid induced hyperalgesia (OIH), and this has been widely reported both clinically and experimentally. The molecular substrate for this hyperalgesia is multifaceted, and associated with a complex neural reorganization even...
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| Опубликовано в: : | J Pain |
|---|---|
| Главные авторы: | , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
2016
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC5291755/ https://ncbi.nlm.nih.gov/pubmed/27845197 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jpain.2016.10.015 |
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