Genome-Wide Identification of Host Genes Required for Toxicity of Bacterial Cytolethal Distending Toxin in a Yeast Model

BACKGROUND: Aggregatibacter actinomycetemcomitans, a periodontal pathogen, secretes a cytolethal distending toxin (AaCDT) that causes host cell cycle arrest and cell death. Although CDT could be an important virulence factor, it is unclear how it enters the nucleus to exert its cytotoxicity. OBJECTI...

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Detalhes bibliográficos
Publicado no:Front Microbiol
Main Authors: Denmongkholchai, Siriyod, Katare, Prashant, Choochuay, Sarocha, Thanyasrisung, Panida, Tsuruda, Keiko, Sugai, Motoyuki, Mongkolsuk, Skorn, Matangkasombut, Oranart
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Microbiology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497811/
https://ncbi.nlm.nih.gov/pubmed/31080443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.00890
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