Genome-Wide Identification of Host Genes Required for Toxicity of Bacterial Cytolethal Distending Toxin in a Yeast Model

BACKGROUND: Aggregatibacter actinomycetemcomitans, a periodontal pathogen, secretes a cytolethal distending toxin (AaCDT) that causes host cell cycle arrest and cell death. Although CDT could be an important virulence factor, it is unclear how it enters the nucleus to exert its cytotoxicity. OBJECTI...

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Gorde:
Xehetasun bibliografikoak
Argitaratua izan da:Front Microbiol
Egile Nagusiak: Denmongkholchai, Siriyod, Katare, Prashant, Choochuay, Sarocha, Thanyasrisung, Panida, Tsuruda, Keiko, Sugai, Motoyuki, Mongkolsuk, Skorn, Matangkasombut, Oranart
Formatua: Artigo
Hizkuntza:Inglês
Argitaratua: Frontiers Media S.A. 2019
Gaiak:
Microbiology
Sarrera elektronikoa:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497811/
https://ncbi.nlm.nih.gov/pubmed/31080443
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fmicb.2019.00890
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