Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

Polyglutamine (polyQ) tracts are regions of low sequence complexity frequently found in transcription factors. Tract length often correlates with transcriptional activity and expansion beyond specific thresholds in certain human proteins is the cause of polyQ disorders. To study the structural basis...

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Publicat a:Nat Commun
Autors principals: Escobedo, Albert, Topal, Busra, Kunze, Micha B. A., Aranda, Juan, Chiesa, Giulio, Mungianu, Daniele, Bernardo-Seisdedos, Ganeko, Eftekharzadeh, Bahareh, Gairí, Margarida, Pierattelli, Roberta, Felli, Isabella C., Diercks, Tammo, Millet, Oscar, García, Jesús, Orozco, Modesto, Crehuet, Ramon, Lindorff-Larsen, Kresten, Salvatella, Xavier
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497633/
https://ncbi.nlm.nih.gov/pubmed/31048691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09923-2
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