Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

Polyglutamine (polyQ) tracts are regions of low sequence complexity frequently found in transcription factors. Tract length often correlates with transcriptional activity and expansion beyond specific thresholds in certain human proteins is the cause of polyQ disorders. To study the structural basis...

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Pubblicato in:Nat Commun
Autori principali: Escobedo, Albert, Topal, Busra, Kunze, Micha B. A., Aranda, Juan, Chiesa, Giulio, Mungianu, Daniele, Bernardo-Seisdedos, Ganeko, Eftekharzadeh, Bahareh, Gairí, Margarida, Pierattelli, Roberta, Felli, Isabella C., Diercks, Tammo, Millet, Oscar, García, Jesús, Orozco, Modesto, Crehuet, Ramon, Lindorff-Larsen, Kresten, Salvatella, Xavier
Natura: Artigo
Lingua:Inglês
Pubblicazione: Nature Publishing Group UK 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497633/
https://ncbi.nlm.nih.gov/pubmed/31048691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09923-2
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