Side chain to main chain hydrogen bonds stabilize a polyglutamine helix in a transcription factor

Polyglutamine (polyQ) tracts are regions of low sequence complexity frequently found in transcription factors. Tract length often correlates with transcriptional activity and expansion beyond specific thresholds in certain human proteins is the cause of polyQ disorders. To study the structural basis...

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Bibliographic Details
Published in:Nat Commun
Main Authors: Escobedo, Albert, Topal, Busra, Kunze, Micha B. A., Aranda, Juan, Chiesa, Giulio, Mungianu, Daniele, Bernardo-Seisdedos, Ganeko, Eftekharzadeh, Bahareh, Gairí, Margarida, Pierattelli, Roberta, Felli, Isabella C., Diercks, Tammo, Millet, Oscar, García, Jesús, Orozco, Modesto, Crehuet, Ramon, Lindorff-Larsen, Kresten, Salvatella, Xavier
Format: Artigo
Language:Inglês
Published: Nature Publishing Group UK 2019
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Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497633/
https://ncbi.nlm.nih.gov/pubmed/31048691
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09923-2
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