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Hypoxia Associated Factor (HAF) mediates neurofibromin ubiquitination and degradation leading to Ras-ERK pathway activation in hypoxia
Low oxygen or hypoxia is a feature of all solid tumors, and has been associated with aggressive disease. Here, we describe a novel mechanism for the hypoxia-dependent degradation of the Ras-GTPase activating protein neurofibromin, by hypoxia-associated factor (HAF). We have previously characterized...
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| Publicat a: | Mol Cancer Res |
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| Autors principals: | , , , , , , |
| Format: | Artigo |
| Idioma: | Inglês |
| Publicat: |
2019
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| Matèries: | |
| Accés en línia: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6497562/ https://ncbi.nlm.nih.gov/pubmed/30705246 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-1080 |
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