Interaction between MUC1 and STAT1 drives IFITM1 overexpression in aromatase inhibitor-resistant breast cancer cells and mediates estrogen-induced apoptosis

The human oncoprotein, mucin 1 (MUC1), drives tumorigenesis in breast carcinomas by promoting epithelial-mesenchymal transition (EMT), epigenetic reprogramming, and evasion of immune response. MUC1 interacts with STAT1, through JAK/STAT signaling, and stimulates transcription of interferon-stimulate...

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Détails bibliographiques
Publié dans:Mol Cancer Res
Auteurs principaux: Escher, Taylor E., Lui, Asona J., Geanes, Eric S., Walter, Katherine R., Tawfik, Ossama, Hagan, Christy R., Lewis-Wambi, Joan
Format: Artigo
Langue:Inglês
Publié: 2019
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Article
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497545/
https://ncbi.nlm.nih.gov/pubmed/30655323
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-18-0916
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