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The Use of Somatic Hypermutation for the Affinity Maturation of Therapeutic Antibodies
The engineering of antibodies and antibody fragments for affinity maturation, stability, and other biophysical characteristics is a common aspect of therapeutic development. Maturation of antibodies in B cells during the adaptive immune response is the result of a process called somatic hypermutatio...
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| Udgivet i: | Methods Mol Biol |
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| Main Authors: | , , |
| Format: | Artigo |
| Sprog: | Inglês |
| Udgivet: |
2018
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| Fag: | |
| Online adgang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6497467/ https://ncbi.nlm.nih.gov/pubmed/30196512 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/978-1-4939-8648-4_24 |
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