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Intricate targeting of immunoglobulin somatic hypermutation maximizes the efficiency of affinity maturation
It is believed that immunoglobulin-variable region gene (IgV) somatic hypermutation (SHM) is initiated by activation-induced cytidine deaminase (AID) upon deamination of cytidine to deoxyuracil. Patch-excision repair of these lesions involving error prone DNA polymerases such as polη causes mutation...
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| Principais autores: | , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
The Rockefeller University Press
2005
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC2213188/ https://ncbi.nlm.nih.gov/pubmed/15867095 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1084/jem.20042483 |
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