Pretreatment With PCSK9 Inhibitor Protects the Brain Against Cardiac Ischemia/Reperfusion Injury Through a Reduction of Neuronal Inflammation and Amyloid Beta Aggregation

BACKGROUND: Cardiac ischemic/reperfusion (I/R) injury leads to brain damage. A new antihyperlipidemic drug is aimed at inhibiting PCSK9 (proprotein convertase subtilisin/kexin type 9), a molecule first identified in a neuronal apoptosis paradigm. Thus, the PCSK9 inhibitor (PCSK9i) may play a role in...

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Detalhes bibliográficos
Publicado no:J Am Heart Assoc
Main Authors: Apaijai, Nattayaporn, Moisescu, Dalila Monica, Palee, Siripong, McSweeney, Christian Mervyn, Saiyasit, Napatsorn, Maneechote, Chayodom, Boonnag, Chiraphat, Chattipakorn, Nipon, Chattipakorn, Siriporn C.
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Research
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497363/
https://ncbi.nlm.nih.gov/pubmed/30636486
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1161/JAHA.118.010838
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