PCSK9 inhibitor improves cardiac function and reduces infarct size in rats with ischaemia/reperfusion injury: Benefits beyond lipid‐lowering effects

During acute cardiac ischaemia/reperfusion (I/R), an increased plasma proprotein convertase subtilisin/kexin 9 (PCSK9) level instigates inflammatory and oxidative processes within ventricular myocytes, resulting in cardiac dysfunction. Therefore, PCSK9 inhibitor (PCSK9i) might exert cardioprotection...

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Detalhes bibliográficos
Publicado no:J Cell Mol Med
Main Authors: Palee, Siripong, McSweeney, Christian M., Maneechote, Chayodom, Moisescu, Dalila M., Jaiwongkam, Thidarat, Kerdphoo, Sasiwan, Chattipakorn, Siriporn C., Chattipakorn, Nipon
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
Assuntos:
Original Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6815840/
https://ncbi.nlm.nih.gov/pubmed/31557388
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/jcmm.14586
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