Combined Vildagliptin and Metformin Exert Better Cardioprotection than Monotherapy against Ischemia-Reperfusion Injury in Obese-Insulin Resistant Rats

BACKGROUND: Obese-insulin resistance caused by long-term high-fat diet (HFD) consumption is associated with left ventricular (LV) dysfunction and increased risk of myocardial infarction. Metformin and vildagliptin have been shown to exert cardioprotective effects. However, the effect of these drugs...

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Bibliografske podrobnosti
Main Authors: Apaijai, Nattayaporn, Chinda, Kroekkiat, Palee, Siripong, Chattipakorn, Siriporn, Chattipakorn, Nipon
Format: Artigo
Jezik:Inglês
Izdano: Public Library of Science 2014
Teme:
Research Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC4103813/
https://ncbi.nlm.nih.gov/pubmed/25036861
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0102374
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