Simulated human digestion of N1-aryl-2-arylthioacetamidobenzimidazoles and their activity against Herpes-simplex virus 1 in vitro

Drug performance in the gastrointestinal tract (GIT) plays a crucial role in determining release and absorption. In the present work, we assessed the in vitro digestion of two synthetic N1-aryl-2-arylthioacetamidobenzimidazoles (NAABs), NAAB-496 and NAAB-503, using bio-relevant models of the human s...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Mandalari, Giuseppina, Bisignano, Carlo, Smeriglio, Antonella, Denaro, Marcella, Musarra-Pizzo, Maria, Pennisi, Rosamaria, Mancuso, Francesca, Ferro, Stefania, Trombetta, Domenico, Monforte, Anna Maria, Sciortino, Maria Teresa, De Luca, Laura
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497310/
https://ncbi.nlm.nih.gov/pubmed/31048874
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0216384
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