Antibody Fab‐Fc properties outperform titer in predictive models of SIV vaccine‐induced protection

Characterizing the antigen‐binding and innate immune‐recruiting properties of the humoral response offers the chance to obtain deeper insights into mechanisms of protection than revealed by measuring only overall antibody titer. Here, a high‐throughput, multiplexed Fab‐Fc Array was employed to profi...

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Publicado no:Mol Syst Biol
Main Authors: Pittala, Srivamshi, Bagley, Kenneth, Schwartz, Jennifer A, Brown, Eric P, Weiner, Joshua A, Prado, Ilia J, Zhang, Wenlei, Xu, Rong, Ota‐Setlik, Ayuko, Pal, Ranajit, Shen, Xiaoying, Beck, Charles, Ferrari, Guido, Lewis, George K, LaBranche, Celia C, Montefiori, David C, Tomaras, Georgia D, Alter, Galit, Roederer, Mario, Fouts, Timothy R, Ackerman, Margaret E, Bailey‐Kellogg, Chris
Formato: Artigo
Idioma:Inglês
Publicado em: John Wiley and Sons Inc. 2019
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Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497031/
https://ncbi.nlm.nih.gov/pubmed/31048360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20188747
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