Antibody Fab‐Fc properties outperform titer in predictive models of SIV vaccine‐induced protection

Characterizing the antigen‐binding and innate immune‐recruiting properties of the humoral response offers the chance to obtain deeper insights into mechanisms of protection than revealed by measuring only overall antibody titer. Here, a high‐throughput, multiplexed Fab‐Fc Array was employed to profi...

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Publicado en:Mol Syst Biol
Autores principales: Pittala, Srivamshi, Bagley, Kenneth, Schwartz, Jennifer A, Brown, Eric P, Weiner, Joshua A, Prado, Ilia J, Zhang, Wenlei, Xu, Rong, Ota‐Setlik, Ayuko, Pal, Ranajit, Shen, Xiaoying, Beck, Charles, Ferrari, Guido, Lewis, George K, LaBranche, Celia C, Montefiori, David C, Tomaras, Georgia D, Alter, Galit, Roederer, Mario, Fouts, Timothy R, Ackerman, Margaret E, Bailey‐Kellogg, Chris
Formato: Artigo
Lenguaje:Inglês
Publicado: John Wiley and Sons Inc. 2019
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Articles
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497031/
https://ncbi.nlm.nih.gov/pubmed/31048360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20188747
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