Antibody Fab‐Fc properties outperform titer in predictive models of SIV vaccine‐induced protection

Characterizing the antigen‐binding and innate immune‐recruiting properties of the humoral response offers the chance to obtain deeper insights into mechanisms of protection than revealed by measuring only overall antibody titer. Here, a high‐throughput, multiplexed Fab‐Fc Array was employed to profi...

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Publicat a:Mol Syst Biol
Autors principals: Pittala, Srivamshi, Bagley, Kenneth, Schwartz, Jennifer A, Brown, Eric P, Weiner, Joshua A, Prado, Ilia J, Zhang, Wenlei, Xu, Rong, Ota‐Setlik, Ayuko, Pal, Ranajit, Shen, Xiaoying, Beck, Charles, Ferrari, Guido, Lewis, George K, LaBranche, Celia C, Montefiori, David C, Tomaras, Georgia D, Alter, Galit, Roederer, Mario, Fouts, Timothy R, Ackerman, Margaret E, Bailey‐Kellogg, Chris
Format: Artigo
Idioma:Inglês
Publicat: John Wiley and Sons Inc. 2019
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Articles
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6497031/
https://ncbi.nlm.nih.gov/pubmed/31048360
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/msb.20188747
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