Differences in the Likelihood of Acyclovir Resistance-Associated Mutations in the Thymidine Kinase Genes of Herpes Simplex Virus 1 and Varicella-Zoster Virus

Acyclovir (ACV) resistance-associated mutations in two recombinant herpes simplex virus 1 (HSV-1) clones were compared. Recombinant HSV-1 lacking its thymidine kinase (TK) and expressing varicella-zoster virus (VZV) TK ectopically had no mutations in the VZV TK gene. In contrast, recombinant HSV-1 e...

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Bibliographische Detailangaben
Veröffentlicht in:Antimicrob Agents Chemother
Hauptverfasser: Fujii, Hikaru, Harada, Shizuko, Yoshikawa, Tomoki, Yamada, Souichi, Omura, Natsumi, Shibamura, Miho, Inagaki, Takuya, Kato, Hirofumi, Fukushi, Shuetsu, Saijo, Masayuki
Format: Artigo
Sprache:Inglês
Veröffentlicht: American Society for Microbiology 2019
Schlagworte:
Antiviral Agents
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496055/
https://ncbi.nlm.nih.gov/pubmed/30858222
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.00017-19
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