Association between sensitivity of viral thymidine kinase-associated acyclovir-resistant herpes simplex virus type 1 and virulence

BACKGROUND: Acyclovir (ACV)-resistant (ACVr) herpes simplex virus type 1 (HSV-1) infections are concern in immunocompromised patients. Most clinical ACVr HSV-1 isolates have mutations in the viral thymidine kinase (vTK) genes. The vTK-associated ACVr HSV-1 shows reduced virulence, but the associatio...

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Vydáno v:Virol J
Hlavní autoři: Omura, Natsumi, Fujii, Hikaru, Yoshikawa, Tomoki, Yamada, Souichi, Harada, Shizuko, Inagaki, Takuya, Shibamura, Miho, Takeyama, Haruko, Saijo, Masayuki
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2017
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC5359899/
https://ncbi.nlm.nih.gov/pubmed/28320407
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12985-017-0728-2
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