Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations

Fluoroquinolones represent the pillar of multidrug-resistant tuberculosis (MDR-TB) treatment, with moxifloxacin, levofloxacin, or gatifloxacin being prescribed to MDR-TB patients. Recently, several clinical trials of “universal” drug regimens, aiming to treat drug-susceptible and drug-resistant TB,...

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Detalhes bibliográficos
Publicado no:Antimicrob Agents Chemother
Main Authors: Sarathy, Jansy, Blanc, Landry, Alvarez-Cabrera, Nadine, O’Brien, Paul, Dias-Freedman, Isabela, Mina, Marizel, Zimmerman, Matthew, Kaya, Firat, Ho Liang, Hsin-Pin, Prideaux, Brendan, Dietzold, Jillian, Salgame, Padmini, Savic, Radojka M., Linderman, Jennifer, Kirschner, Denise, Pienaar, Elsje, Dartois, Véronique
Formato: Artigo
Idioma:Inglês
Publicado em: American Society for Microbiology 2019
Assuntos:
Pharmacology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6496041/
https://ncbi.nlm.nih.gov/pubmed/30803965
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/AAC.02516-18
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