Human ovarian surface epithelial cells immortalized with hTERT maintain functional pRb and p53 expression

Abstract.  Objective: Cell immortalization is considered to be a prerequisite status for carcinogenesis. Normal human ovarian surface epithelial (OSE) cells, which are thought to be the origin of most of human ovarian carcinomas, have a very limited lifespan in culture. Establishment of immortalized...

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Bibliographic Details
Published in:Cell Prolif
Main Authors: Li, N. F., Broad, S., Lu, Y. J., Yang, J. S., Watson, R., Hagemann, T., Wilbanks, G., Jacobs, I., Balkwill, F., Dafou, D., Gayther, S. A.
Format: Artigo
Language:Inglês
Published: Blackwell Publishing Ltd 2007
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Original Articles
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6495942/
https://ncbi.nlm.nih.gov/pubmed/17877616
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1365-2184.2007.00462.x
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