Steroidal antibiotics are antimetabolites of Acanthamoeba steroidogenesis with phylogenetic implications

Pathogenic organisms may be sensitive to inhibitors of sterol biosynthesis, which carry antimetabolite properties, through manipulation of the key enzyme, sterol methyltransferase (SMT). Here, we isolated natural suicide substrates of the ergosterol biosynthesis pathway, cholesta-5,7,22,24-tetraenol...

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Detalhes bibliográficos
Publicado no:J Lipid Res
Main Authors: Zhou, Wenxu, Ramos, Emilio, Zhu, Xunlu, Fisher, Paxtyn M., Kidane, Medhanie E., Vanderloop, Boden H., Thomas, Crista D., Yan, Juqiang, Singha, Ujjal, Chaudhuri, Minu, Nagel, Michael T., Nes, W. David
Formato: Artigo
Idioma:Inglês
Publicado em: The American Society for Biochemistry and Molecular Biology 2019
Assuntos:
Research Articles
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6495176/
https://ncbi.nlm.nih.gov/pubmed/30709898
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1194/jlr.M091587
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