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Functional Importance for Developmental Regulation of Sterol Biosynthesis in Acanthamoeba castellanii
The sterol metabolome of Acanthamoeba castellanii (Ac) yielded 25 sterols. Substrate screening of cloned AcCYP51 revealed obtusifoliol as the natural substrate which converts to Δ(8,14)-sterol (<95%). The combination of [(2)H(3)-methyl]methionine incubation to intact cultures showing C(28-)ergost...
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| Publicado no: | Biochim Biophys Acta Mol Cell Biol Lipids |
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| Main Authors: | , , , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
2018
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6180906/ https://ncbi.nlm.nih.gov/pubmed/30044954 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2018.07.004 |
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