Functional Importance for Developmental Regulation of Sterol Biosynthesis in Acanthamoeba castellanii

The sterol metabolome of Acanthamoeba castellanii (Ac) yielded 25 sterols. Substrate screening of cloned AcCYP51 revealed obtusifoliol as the natural substrate which converts to Δ(8,14)-sterol (<95%). The combination of [(2)H(3)-methyl]methionine incubation to intact cultures showing C(28-)ergost...

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Publicat a:Biochim Biophys Acta Mol Cell Biol Lipids
Autors principals: Zhou, Wenxu, Warrilow, Andrew G.S., Thomas, Crista D., Ramos, Emilio, Parker, Josie E., Price, Claire L., Vanderloop, Boden H., Fisher, Paxtyn M., Loftis, Michael D., Kelly, Diane E., Kelly, Steven L., Nes, W. David
Format: Artigo
Idioma:Inglês
Publicat: 2018
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6180906/
https://ncbi.nlm.nih.gov/pubmed/30044954
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.bbalip.2018.07.004
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