SIRT1 deacetylated and stabilized XRCC1 to promote chemoresistance in lung cancer

Chemoresistance is one of the most important challenges in the clinical management of lung cancer. SIRT1 is a NAD dependent protein deacetylase and implicated in diverse cellular processes such as DNA damage repair, and cancer progression. SIRT1 is upregulated in chemoresistant lung cancer cells, ge...

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Veröffentlicht in:Cell Death Dis
Hauptverfasser: Yousafzai, Neelum Aziz, Zhou, Qiyin, Xu, Wenxia, Shi, Qiqi, Xu, Jinye, Feng, Lifeng, Chen, Hui, Shin, Vivian Yvonne, Jin, Hongchuan, Wang, Xian
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Publishing Group UK 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494911/
https://ncbi.nlm.nih.gov/pubmed/31043584
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-1592-3
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