Improved contrast of affibody-mediated imaging of HER3 expression in mouse xenograft model through co-injection of a trivalent affibody for in vivo blocking of hepatic uptake

Human epidermal growth factor receptor type 3 (HER3) plays a crucial role in the progression of many cancer types. In vivo radionuclide imaging could be a reliable method for repetitive detection of HER3-expression in tumors. The main challenge of HER3-imaging is the low expression in tumors togethe...

Disgrifiad llawn

Wedi'i Gadw mewn:
Manylion Llyfryddiaeth
Cyhoeddwyd yn:Sci Rep
Prif Awduron: Rosestedt, Maria, Andersson, Ken G., Rinne, Sara S., Leitao, Charles Dahlsson, Mitran, Bogdan, Vorobyeva, Anzhelika, Ståhl, Stefan, Löfblom, John, Tolmachev, Vladimir, Orlova, Anna
Fformat: Artigo
Iaith:Inglês
Cyhoeddwyd: Nature Publishing Group UK 2019
Pynciau:
Article
Mynediad Ar-lein:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494909/
https://ncbi.nlm.nih.gov/pubmed/31043683
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-43145-2
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