Structural basis for reversible amyloids of hnRNPA1 elucidates their role in stress granule assembly

Subcellular membrane-less organelles consist of proteins with low complexity domains. Many of them, such as hnRNPA1, can assemble into both a polydisperse liquid phase and an ordered solid phase of amyloid fibril. The former mirrors biological granule assembly, while the latter is usually associated...

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Udgivet i:Nat Commun
Main Authors: Gui, Xinrui, Luo, Feng, Li, Yichen, Zhou, Heng, Qin, Zhenheng, Liu, Zhenying, Gu, Jinge, Xie, Muyun, Zhao, Kun, Dai, Bin, Shin, Woo Shik, He, Jianhua, He, Lin, Jiang, Lin, Zhao, Minglei, Sun, Bo, Li, Xueming, Liu, Cong, Li, Dan
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494871/
https://ncbi.nlm.nih.gov/pubmed/31043593
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-09902-7
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