The nuclear localization sequence mediates hnRNPA1 amyloid fibril formation revealed by cryoEM structure

Human heterogeneous nuclear ribonucleoprotein A1 (hnRNPA1) serves as a key regulating protein in RNA metabolism. Malfunction of hnRNPA1 in nucleo-cytoplasmic transport or dynamic phase separation leads to abnormal amyloid aggregation and neurodegeneration. The low complexity (LC) domain of hnRNPA1 d...

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Bibliografske podrobnosti
izdano v:Nat Commun
Main Authors: Sun, Yunpeng, Zhao, Kun, Xia, Wencheng, Feng, Guoqin, Gu, Jinge, Ma, Yeyang, Gui, Xinrui, Zhang, Xia, Fang, Yanshan, Sun, Bo, Wang, Renxiao, Liu, Cong, Li, Dan
Format: Artigo
Jezik:Inglês
Izdano: Nature Publishing Group UK 2020
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Article
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC7733464/
https://ncbi.nlm.nih.gov/pubmed/33311513
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-020-20227-8
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