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Downregulation of thromboxane A2 and angiotensin II type 1 receptors associated with aging-related decrease in internal anal sphincter tone

Aging-associated decrease in internal anal sphincter (IAS) tone (AADI) is a major contributor in the rectoanal incontinence (RI). To determine the pathogenesis of AADI, we investigated the effect of aging on GPCR activation and related downstream signaling. We particularly investigated two GPCRs tha...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Mohanty, Ipsita, Singh, Jagmohan, Rattan, Satish
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494869/
https://ncbi.nlm.nih.gov/pubmed/31043680
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-42894-4
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