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Revisiting the Functional Role of Dopamine D(4) Receptor Gene Polymorphisms: Heteromerization-Dependent Gain of Function of the D(4.7) Receptor Variant

The two most common polymorphisms of the human DRD4 gene encode a dopamine D(4) receptor (D4R) with four or seven repeats of a proline-rich sequence of 16 amino acids (D4.4R or D4.7R). Although the seven-repeat polymorphism has been repeatedly associated with attention deficit hyperactivity disorder...

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Dettagli Bibliografici
Pubblicato in:Mol Neurobiol
Autori principali: Sánchez-Soto, Marta, Yano, Hideaki, Cai, Ning-Sheng, Casadó-Anguera, Verònica, Moreno, Estefanía, Casadó, Vicent, Ferré, Sergi
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2018
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Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6494742/
https://ncbi.nlm.nih.gov/pubmed/30387076
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s12035-018-1413-1
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