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Ascomycin and FK506: Pharmacology and Therapeutic Potential as Anticonvulsants and Neuroprotectants
Ascomycin and FK506 are powerful calcium‐dependent serine/threonine protein phosphatase (calcineurin [CaN], protein phosphatase 2B) inhibitors. Their mechanism of action involves the formation of a molecular complex with the intracellular FK506‐binding protein‐12 (FKBP12), thereby acquiring the abil...
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| Veröffentlicht in: | CNS Neurosci Ther |
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| Hauptverfasser: | , |
| Format: | Artigo |
| Sprache: | Inglês |
| Veröffentlicht: |
Blackwell Publishing Inc
2008
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| Schlagworte: | |
| Online Zugang: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6494028/ https://ncbi.nlm.nih.gov/pubmed/18482098 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1111/j.1527-3458.2008.00036.x |
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