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The immunosuppressive and toxic effects of FK-506 are mechanistically related: pharmacology of a novel antagonist of FK-506 and rapamycin

FK-506 inhibits Ca(2+)-dependent transcription of lymphokine genes in T cells, and thereby acts as a powerful immunosuppressant. However, its potential therapeutic applications may be seriously limited by several side effects, including nephrotoxicity and neurotoxicity. At present, it is unclear whe...

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Médium: Artigo
Jazyk:Inglês
Vydáno: The Rockefeller University Press 1992
Témata:
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC2119351/
https://ncbi.nlm.nih.gov/pubmed/1380976
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